منابع مشابه
Cryptic messages: is noncoagulant tissue factor reserved for cell signaling?
T issue factor (TF) is the principal initiator of blood clotting in response to vascular injury and in thrombotic disease (1). TF, an integral membrane protein, is normally excluded from the vascular compartment. Coagulation is initiated when TF is exposed to zymogen coagulation proteases in plasma upon vascular damage. TF first binds factor VII, supporting both its activation to VIIa and activ...
متن کاملAPC+/− alters colonic fibroblast proteome in FAP
Here we compared the proteomes of primary fibroblast cultures derived from morphologically normal colonic mucosa of familial adenomatous polyposis (FAP) patients with those obtained from unaffected controls. The expression signature of about 19% of total fibroblast proteins separates FAP mutation carriers from unaffected controls (P < 0.01). More than 4,000 protein spots were quantified by 2D P...
متن کاملBiopsy experience in a FAP endemic area
Results Until 1988, nerve and skin biopsies were commonly performed for diagnostic purposes, after that with genetic testing being available all tissue biopsies declined in number and were only needed in difficult diagnostic cases or when genetic testing was not available. Nerve biopsy became relevant again with the appearance of atypical clinical presentations or late onset or sporadic patient...
متن کاملTherapeutic education programme in TTR-FAP
Background The French National Reference centre for Transthyretinrelated amyloidosis (ATTR) was accredited in 2005. One of its 10 lines of action is to inform and educate patients about their disease to improve their care and reduce morbidities. We thus decided to elaborate a therapeutic patient education (TPE) programme, starting with patients’ needs assessment. We will describe our needs asse...
متن کاملNeurophysiological pitfalls in TTR-FAP Val30Met
Introduction The neurological hallmark of TTR-FAP is a lengthdependent axonal neuropathy that initially involves the unmyelinated and small myelinated nerve fibers that mediate pain and temperature sensation, causing sensory disturbances that typically start in lower limbs. Subsequent degeneration of larger myelinated fibers results in large fiber sensory deficit and muscle weakness. The diseas...
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ژورنال
عنوان ژورنال: Gut
سال: 1999
ISSN: 0017-5749
DOI: 10.1136/gut.45.6.795